Testofen™ – Fenugreek Extract Standardised for 50% Fenuside

Fenugreek is a well-known herb, containing a variety of compounds as active ingredients. It is an extremely versatile herb with multiple applications. This amazing herb is said to contain more than a 100 phytochemical constituents. Amongst them are a lot of Furostanol Saponins and Steroidal Saponins.

Testofen™ helps promote healthy Testosterone levels. In addition, it seems to act like Testosterone to promote libido. The following are clinical studies done on Testofen™:

1.- Human Clinical Study for Free Testosterone and Muscle Mass Boosting:

This study was conducted in 2008 on 60 healthy men and was placebo-controlled and double-blind. Half of the group took 600mg of Testofen per day and the other half took 600mg of a placebo. Both groups also participated in resistance training exercises throughout the eight week study. The primary findings were as follows:

• Testofen group experienced a significant increase in Free Testosterone (p<0.05) compared to the Placebo group.
• Testofen group TESTOFEN® group demonstrated significant anabolic activity as evidenced by BUN reduction (p<0.05) compared to the Placebo group.
• Testofen group has not only compensated the loss of Immunity typically associated with exercise compared to Placebo (p<0.003) and also increased immunity.
• Testofen group showed significant reduction in Serum Creatinine levels (p<0.02) compared to Placebo group signifying Creatine uptake and recycle in muscle cells.
• Testofen group showed a significant increase in Prolactin compared to Placebo (p<0.04). However this increase is within Physiological limits for men.
• Testofen group showed a significant decrease in body fat compared to baseline.
• Testofen group maintained Muscle size despite maintaining weight and reducing fat.

Read the study:

2.- Clinical Study for Improvement of Male Sexual Function:

This study was conducted in 2009 on 60 health adult men and was placebo-controlled and double-blind. Half of the group took 600mg of Testofen per day along with some other basic minerals including Magnesium, Zinc and Vitamin B6 and the other took placebo. This study involved no exercise regimen. The primary findings were as follows:

• Testofen has an overall positive effect on sexual function, performance, and satisfaction (libido) in healthy adult males.
• Testofen has a positive effect, on sexual cognition, sexual arousal increases sexual activity and satisfaction with orgasm in healthy adult males.
• Testofen has a positive effect on frequency of sexual activity.
• Testofen has a positive effect on muscle, strength, energy and wellbeing in healthy adult males.
• Testofen does not have an effect on mood and sleep in healthy adult males.
• Prolactin levels and Testosterone levels remained within healthy reference range after 6 weeks of treatment demonstrating that Testofen is safe to use in healthy men to support libido function.
• Testofen may help to maintain healthy testosterone levels.
• Testofen was well tolerated and has no adverse effects when taken as directed over 6 weeks.

The results of this study were also published in a peer-reviewed journal, Phytotherapy Research in 2010.

Read the study:

3.- Testofen Anabolic & Androgenic Activity – Animal Study Summary:

Testofen™ has shown remarkable results in animal studies, showing intracarvenous pressure increase leading to healthy erectile functions. It has demonstrated excellent results in animal studies for promoting healthy testosterone and Libido and Muscle Mass.

• All the three test groups showed statistically significant activity over the placebo group. Mounting frequency and intromission frequency increased, mounting latency and intromission latency decreased, ejaculation latency increased and post ejaculation interval levels decreased.
• The 25 mg / kg body weight fed test group, showed comparable activity to the positive control group with Sildenafil Citrate.
• Testosterone levels increased significantly in the entire test group compared to the placebo group. Testosterone levels did not increase in the positive control group, which were fed with Sildenafil Citrate.
• Androgenic Activity increase was observed in the test group, which were significantly higher than the placebo group and the positive control group.
• There was no blood pressure drop in either the test groups or the placebo group. There was a 23 % drop in blood pressure in the positive control group due to side effects of the drug Sildenafil Citrate.
• Muscle mass increase was observed in the entire test group.

The results of this study were also published in a peer-reviewed journal, Phytotherapy Research in 2010.

Read the study:

References:

1. Urmila Aswar et.atl, Effect of Furostanol Glycosides from Trigonella foenum –graecum on the reproductive system of Male Albino Rats. Phytother. Res. 24: 1482–1488 (2010)
2. Effect of TESTOFEN on safety, anabolic activity and factors affecting Exercise Physiology. Wankhede et. al. To be published.
3. Phytotherapy Research. Published online ahead of print, doi: 10.1002/ptr.3360 “Physiological Aspects of Male Libido Enhanced by Standardized Trigonella foenum-graecum Extract and Mineral Formulation” Authors: E. Steels, A. Rao, L. Vitetta

Research on the effectiveness of some of the main nutrients in Ultra T Gold™:

L-arginine

• L-arginine is converted in the body into a chemical called nitric oxide. Nitric oxide causes blood vessels to open wider for improved blood flow. L-arginine also stimulates the release of growth hormone, insulin, and other substances in the body. Read more>

Saw Palmetto

• Saw palmetto is best known for its use in decreasing symptoms of an enlarged prostate (benign prostatic hypertrophy, BPH). According to many research studies, it is effective for this use. Read more>

Tribulus terrestris

• Tribulus is a plant that produces fruit covered with spines and is connected with many male health issues. Read more>

Asian Ginseng

• Asian Ginseng is used for improving thinking, concentration, memory and work efficiency, physical stamina, and athletic endurance. Read more>

Astralagus Root

• Astralagus Root is known to assist blood circulation and increase energy in the body. Read more>

Phytosterol

• Phytosterol (40% Beta Sitosterol) supports prostate health and supports cardiovascular health. Read more>

Testofen® and fenusides are a registered trademark of Gencor Nutrients.

Vitali-T-Aid component Testofen, a standardized Trigonellafoenum-graecum (Fenugreek) extract and mineral formulation, demonstrated a significant positive effect on physiological aspects of male libido and may assist to maintain normal healthy testosterone levels. Researchers Elizabeth Steels and Amanda Rao from Applied Science and Nutrition Pty Ltd and Luis Vitetta from The University of Queensland, Brisbane, Australia, recruited 60 healthy males aged between 25 and 52, without erectile dysfunction (ED) and randomized them to an oral dose (two tablets per day) of either 600 mg/d Testofen or a placebo for six weeks. The primary outcome measure was the DIS-SR (male) self-administered QOL total score and the four domain scores. The secondary outcome was specific quality of life parameters. The same 600mg dosage equals the amount of Testofen in one serving of Vitali-T-Aid. Each daily dose of Vitali-T-Aid also contains a proprietary Male Enhancement Blend of L-Arginine and beneficial herbs, such as Saw Palmetto, Astragalus, Tribulus and Asian Ginseng, to help support enhanced male health and well-being. An animal study on Testofen, titled “Effect of Furostanol Glycosides from Trigonellafoenum-graecum on the Reproductive System of Male Albino Rats” was also published in the same journal recently.

One of the key ingredients in Vitali-T-Aid demonstrated an overall positive effect on physiological aspects of libido. In particular, there was a significant increase in sexual arousal and orgasm. Testofen had a positive effect on QOL in self-reported satisfaction with muscle strength, energy and well-being, but did not have an effect on mood or sleep. Serum prolactin and testosterone levels remained within the reference range.

Vitali-T-Aid, a new supplement from Naturade, naturally increases free testosterone levels. In clinical studies on the key studied ingredient, Testofen, free testosterone levels in test subjects were shown to increase by over 98% along with exercise. Testofen acts like testosterone by binding to the testosterone receptor sites and creating testosterone-like activity in the body, thereby supporting healthy free testosterone levels. Studies show that Vitali-T-Aid by Naturade is a natural solution for increasing free testosterone levels and promoting healthy libido, immune function and muscle mass. Vitali-T-Aid natural testosterone booster can be purchased on http://www.vitalitaid.com.

PUNE, India—Furostanol glycosides isolated from fenugreek (as Testofen®, form Gencor ) increased muscle mass in castrated rats without affecting testosterone levels, in a recent study published is Phytotherapy Research ( 24: 1482–1488 (2010). DOI: 10.1002/ptr.3129 ). This anabolic activity has the potential to aid men as they enter so-called male menopause.

Andropause is an old-age disease associated with the loss of libido, loss of muscle mass and associated with decreased testosterone production. As the male body ages, gonadal function slowly declines with a resulting drop in serum testosterone, which can lead to multiple clinical manifestations such as a decrease in bone mass, learning factions, erectile functions, muscle mass and strength. On the other hand, fat mass increases.

Fenugreek ( Trigonella foenum ) has long been used in the traditional Indian systems of medicine for the treatment of various ailments, including sexual health. Western medicine often looks to testosterone replacement to treat erectile dysfunction, which has been shown to compromise the overall quality of life, and increase depression, anxiety and loss of self-esteem. Erectile dysfunction may also signal underlying disease including diabetes, hypertension and cardiovascular disease (CVD). A potential risk of testosterone replacement therapy is an increase in the incidence of prostate cancer.

In the present investigation, Testofen at dose of 35 mg/kg/d significantly increased the weight of the levator ani muscle without increasing the blood urea nitrogen (BUN) similar to exogenous testosterone (10 mg/kg) treatment, indicating anabolic activity. Anabolic agents induce positive nitrogen balance in living organisms. Another bioassay for anabolic activity involves measurement of the increase in weight of the levator ani muscle. This measure correlates well with the nitrogen retention bioassay and the two are usually performed for the determination of anabolic activity.

This current study used Testofen, a furostanol glycoside fraction of Trigonella foenum-graecum , in immature castrated male Wistar rats to investigate anabolic and androgenic activity. The Indian researchers also investigate the effect of Testofen on testicular histology in non-castrated immature rats. Both the castrated and intact rats were divided into the following groups: (I) Control (distilled water), (II) Testofen at 10 mg/kg/d, (III) Testofen at 35 mg/kg/d, (IV) and testosterone (10 mg/kg bi-weekly) for four weeks. At the end of the study, blood was withdrawn, serum testosterone and BUN were measured. Animals were killed and reproductive organs were excised and weighed.

Testosterone increased the body weight of rats significantly (P<0.001) from 151.6 to 254.2 g (68.94 percent increase), whereas the weight of 35-mg/kg-Testofen-treated rats was increased from 151.6 to 193.8 g (28 percent increase). The increase in body weight of 10-mg/kg-Testofen-treated rats was not significant compared with the control group.

Testosterone significantly increased the seminal vesicle, ventral prostate and levator ani weight, but not the penis weight. Testofen at 35 mg/kg, on the other hand, significantly (P<0.001) increased the weights of the levator ani muscle, but failed to increase other organ weights. At the lower dose of 10 mg/kg, Testofen did not increase organ weights.

Testofen at both doses did not change the testosterone level in either the castrated or intact rats, whereas testosterone treatment caused significant (P<0.001) increases in serum testosterone level.

The BUN in castrated rats was 33.44 mg/dL in the control group. The BUN was found to be 18.8 mg/dL in both the higher dose of Testofen and testosterone treatment groups. However, the lower dose of Testofen did not cause a significant change in BUN compared with the control group.

It is postulated that testosterone that is converted peripherally to dihydrotestosterone (DHT) by 5-alpha reductase is responsible for the prostate risk associated with testosterone therapy. DHT has a role in the growth of prostatic tissue and therefore can influence lower urinary tract symptoms. Endogenous testosterone in the circulation can be free (unbound), weakly bound to albumin, or tightly bound to sex hormone binding globulin (SHBG). The free and albumin-bound testosterone is available for use by the body. The largest percentage, however, is bound to SHBG and is unavailable for use in the body.

The results obtained in the present study showed that fenugreek furostanol glycoside possessed anabolic activity (increased muscle mass) without affecting total serum testosterone levels in castrated rats. The probable mechanism for this action may be due to increased availability of testosterone by dissociating it from the stored form, i.e., SHBG.

Source: Testofen.com

ST LOUIS, July 20 /PRNewswire/ — A new study published by the American Society for Reproductive Medicine finds that soyfoods and soy isoflavone supplements have no significant effect on male reproductive hormone levels in men. The literature review indicates that soy does not decrease testosterone levels.

Led by Jill M. Hamilton-Reeves, PhD, RD, of St. Catherine’s University, St. Paul, Minnesota, researchers assessed the effects of soy protein and soy isoflavones on measurements of male reproductive hormones. Findings, just published online in Fertility and Sterility, a publication of the American Society for Reproductive Medicine, demonstrate no significant effect of soy protein or soy isoflavone intake on circulating levels of testosterone, sex hormone-binding globulin or free testosterone in men.

The comprehensive meta-analysis examined the existing scientific literature including all clinical studies examining soy’s effect on male reproductive hormones published before July 1, 2008. Fifteen placebo-controlled treatment groups with baseline and ending measures were analyzed. Thirty-two reports involving 36 treatment groups were also assessed in simpler statistical models. Studies published after July 1, 2008, which were not included in the meta-analysis, support the conclusions of the meta-analysis.

Reproductive endocrinologist William R. Phipps, MD, of the University of Rochester Medical Center, a co-author of the analysis stated, “As a high-quality source of protein that is relatively low in saturated fat, soy can be an important part of a heart-healthy diet and may contribute to a decreased risk of coronary heart disease.” He noted that some men have been reluctant to consume soyfoods due to concerns about estrogen-like effects of soy isoflavones, often referred to as phytoestrogens. But according to Phipps, “it is important for the public to understand that there is no clinical evidence to support these ideas. After conducting a comprehensive review of the existing literature, we found no indication that soy significantly alters male sex hormone levels.”

Men can benefit from soyfood consumption as a means to meet daily protein requirements and at the same time possibly also reducing their risk of heart disease.

Citing the research study, Lisa Kelly, MPH, RD, of the United Soybean Board, added,

“Soy is often praised for the positive role it can play in the diets of women. But, years of clinical research have shown that men stand to benefit from soy, too. I encourage men to incorporate soyfoods into a balanced and varied diet and talk to their healthcare provider about their own unique nutritional needs.”

SOURCE: United Soybean Board

Colostrum, both in healthy subjects and high-risk cardiovascular patients, is at least 3 times more effective than vaccination to prevent flu and is very cost-effective.

Download Journal (4.8Mb PDF)

Study: San Valentino-Spoltore Vascular Screening Project, Department of Biomedical Sciences, G D’annunzio University, Chieti, Pescara, Italy

Authors: Cesarone MR, Belcaro G, Di Renzo A, Dugall M, Cacchio M, Ruffini I, Pellegrini L, Del Boccio G, Fano F, Ledda A, Bottari A, Ricci A, Stuard S, Vinciguerra G.

Via: PubMed.gov

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Researchers say that the amount of the chemical, an antioxidant known as genistein, used in the experiments was no higher than what a human would eat in a soybean-rich diet.

Investigators from Northwestern University found that genistein decreased metastasis of prostate cancer to the lungs by 96 percent compared with mice that did not eat the compound in their chow — making the study the first to demonstrate genistein can stop prostate cancer metastasis in a living organism.

“These impressive results give us hope that genistein might show some effect in preventing the spread of prostate cancer in patients,” said the study’s senior investigator, Raymond C. Bergan, MD, director of experimental therapeutics for the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

“Diet can affect cancer and it doesn’t do it by magic,” Bergan said. “Certain chemicals have beneficial effects and now we have all the preclinical studies we need to suggest genistein might be a very promising chemopreventive drug.”

Bergan and his team have previously demonstrated in prostate cancer cell cultures that genistein inhibits detachment of cancer cells from a primary prostate tumor and represses cell invasion. It does this by blocking activation of p38 MAP kinases, molecules which regulate pathways that activate proteins that loosen cancer cells from their tight hold within a tumor, pushing them to migrate. “In culture, you can actually see that when genistein is introduced, cells flatten themselves in order to spread out and stick strongly to nearby cells,” he said.

In this study, investigators fed genistein to several groups of mice before implanting them with an aggressive form of prostate cancer. The amount of genistein in the blood of the animals was comparable to human blood concentrations after consumption of soy foods, Bergan said.

The researchers found that while genistein didn’t reduce the size of tumors that developed within the prostate, it stopped lung metastasis almost completely. They repeated the experiment and found the same result.

They then examined tissue in the animals, measuring the size of tumor cells’ nuclei to determine if the cells had flattened out in order to spread. “Within a tumor, it is hard to tell where the borders of cells stop, so one way to measure adherence is to look at the size of the nuclei in cells and see if they are wider due to cell spread,” Bergan said. “And that is what we found, demonstrating that the drug is having a primary effect on metastasis.”

He said that the study also found that mice fed genistein expressed higher levels of genes that are involved in cancer cell migration which, Bergan says, at first might not make sense in light of the study’s conclusion that genistein almost completely blocked metastasis.

“What we think is happening here is that the cells we put in the mice normally like to move. When genistein restricted their ability to do so, they tried to compensate by producing more protein involved in migration. But genistein prevented those proteins from being activated,” he said. “This is really a lesson for researchers who depend on biomarker studies to test whether a treatment is working. They need to be aware that those biomarkers might be telling only half of the story.”

Bergan cautioned that much is unknown about use of genistein in preventing cancer spread. For example, it may be that the effects of the compound in people who have eaten soy all their lives is stronger than benefit seen in patients who have only started to use genistein.

“The problem we have faced is that epidemiology studies that found men who eat soy are at reduced risk of prostate cancer death are all associative. They don’t prove anything,” he said. “The only way we will find out how promising genistein is will be from conducting clinical trials.”

Source: http://www.sciencedaily.com/releases/2008/03/080314085038.htm#

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